ABSTRACT
Tolnaftate is an old synthetic topical thiocarbamate antifungal agent with the chemical name 2-naphthyl N-methyl-N-(3-tolyl)thionocarbamate (Adam and Craig, 1965); the chemical structure is shown in Figure 162.1. Clinical use of tolnaftate has declined with the introduction of more potent antifungal compounds such as terbinafine and naftifine. Tolnaftate is used primarily for the treatment of mild to moderate tinea pedis, tinea cruris, tinea corporis, and tinea versicolor (Anon, 1966). It is not indicated for the treatment of onychomycosis due to the lack of drug penetration through the nail plate. Tolnaftate has been successfully used in the treatment of otitis externa caused by certain fungi such as Aspergillus spp. (Zarowny et al., 1975; Liston and Siegel, 1986). Chemical structure of tolnaftate. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig162_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
