ABSTRACT

The hydroxypyridones such as ciclopirox form a class of antimycotics that are not chemically related to the azoles or any other class of antifungal agents. Hydroxypyridones are weak acids that exhibit a broad spectrum of antimicrobial action. For a long time ciclopirox olamine has been the only compound of this class used in clinical practice. Recently, ciclopirox as a free acid and rilopirox (see Chapter 165, Rilopirox) have also been developed.