ABSTRACT
Haloprogin (3-iodo-2-propynyl 2,4,5-trichlorophenyl ether; Halotex cream) has been used as a topical agent for the treatment of dermatophyte infections. Haloprogin was synthesized in 1963 by Seki as one of a series of halophenol-γ-iodopropargyl ethers with antifungal activity (Seki et al., 1963). Haloprogin has activity against dermatophytes, Candida spp., and a limited number of Gram-positive bacteria. This compound is not commercially available in the United States or in the United Kingdom. The structure is shown in Figure 168.1. Chemical structure of haloprogin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig168_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
