ABSTRACT
Pyronaridine (C29H32ClN6O2; 4-[{7-chloro-2-methoxy-pyrido (3,2-b)quinolin-10-yl}amino]-2,6-bis[pyrrolidin-1-ylmethyl] phenol; molecular weight 518.05 g/mol) is a schizonticidal anti-malarial drug belonging to the benzonaphthyridine derivative class (also known as Mannich base derivatives) that has similar structural chemistry to the 4-aminoquinoline drugs (Figure 173.1) (Biagini et al., 2005). It therefore has physicochemical and pharmacokinetic properties and mechanism of action that are broadly similar to those of other aminoquinoline anti-malarials such as chloroquine, amodiaquine, piperaquine, and naphthoquine. Chemical structure of pyronaridine (4-[{7-chloro-2-methoxy-pyrido(3,2-b)quinolin-10-yl}amino]-2,6-bis[pyrrolidin-1-ylmethyl]phenol). https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig173_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
