ABSTRACT
Thiabendazole, also known as tiabendazole, is a benzimidazole anthelmintic synthesized in 1961 by Merck Sharpe & Dhome. It was the original “benzimidazole” anthelmintic, with several hundred analogs being developed in subsequent years by animal health companies. About 20 of these were eventually approved for animal use, of which five (albendazole, mebendazole, triclabendazole, thiabendazole, and flubendazole) were eventually developed and approved for human use. Although it remains commercially available as Mintezol (MSD), its availability is currently very limited owing to its toxicity and the availability of more effective and safer compounds. Thiabendazole is a white, odorless powder that is insoluble in water and only slightly soluble in alcohol. It has the chemical formula -2-(4′-thiazolyl)benzimidazole (C10H7N3S) with a molecular weight of 201.3. Its molecular structure is shown in Figure 202.1. Molecular structure of thiabendazole. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig202_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
