ABSTRACT
Pyrantel, E-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]-pyrimidine, is an imidazothiazole-derived tetrahydropyrimidine. Its anthelmintic activity was first identified in 1966 (Austin et al., 1966). It has been used as a broad-spectrum anthelmintic in both veterinary and human medicine since the 1970s (Kopp et al., 2007b). In humans, it is clinically useful for therapy of three major nematode infections: hookworm (Ancylostoma duodenale and Necator americanus), roundworm (Ascaris lumbricoides), and pinworm (Enterobius vermicularis). In addition, pyrantel pamoate appears to have activity against Trichinella spiralis and Trichostrongylus spp. Pyrantel pamoate is available as a tablet (including chewable) or oral suspension; common preparations include Combantrin (Pfizer), Antiminth (Goerig), and Pyrantrin (Niemeth).
