ABSTRACT

Oxamniquine (Mansil and Vansil, from Pfizer)—developed as UK 4271—was first described in 1969 (Richards and Foster, 1969) as a metabolite of a compound then known as UK 3883 (2-isopropylami-nomethyl-6-methyl-7-nitro-1,2,3,4-tetrahydroquinoline). Oxamniquine is 1,2,3,4-tetrahydro-2-isopropylaminomethyl-7-nitro-6-quinolylmethanol. It is a derivative of hycanthone (Richards and Foster, 1969). The chemical structure is shown in Figure 208.1. Chemical structure of oxamniquine. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig208_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>