ABSTRACT
The nonnucleoside reverse transcriptase inhibitor etravirine (previous investigational names R165335 and TMC125) is a diarylpyrimidine (DAPY) derivative (see Figure 238.1) and is a potent and highly specific inhibitor of the reverse transcriptase of the human immunodeficiency virus type 1 (HIV-1). In limited studies, it has shown significantly weaker activity against HIV-2. Chemical structure of etravirine. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig238_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
