ABSTRACT
Indinavir sulfate (1(1S,2R), 5(S)-2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1-inden-1 -yl)-5-[2-[[(1,1-dimethylethyl) amino] carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-d-erythro-pen-tonamide sulfate (1:1), MK-639, L-735,524) (Crixivan, Merck Inc., Whitehouse Station, NJ) is a hydroxyaminopentane amide and a potent and specific inhibitor of the HIV protease. Indinavir is formulated as a sulfate salt and is available from the manufacturer for oral administration in strengths of 100, 200, 333, and 400 mg of indinavir (corresponding to 125, 250, 416.3, and 500 mg indinavir sulfate, respectively). Indinavir sulfate is a white to off-white, hygroscopic, crystalline powder with the molecular formula C36H47N5 H2SO4 and a molecular weight of 711.88 Da. The chemical structure of indinavir is shown in Figure 241.1. The molecular weight of indinavir free base is 613.8 Da. Chemical structure of indinavir sulfate. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig241_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
