ABSTRACT
Atazanavir (ATV) sulfate, (3S,8S,9S,12S)-3,12-bis(1,1-dimethyl-ethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pentaazate-tradecanedioic acid dimethyl ester sulfate (1:1), previously known as BMS-232632, is an azapeptide inhibitor of HIV-1 protease. The trade name for atazanavir is Reyataz (access-data.fda.gov/drugsatfda_docs/label/2007/021567s012lbl. pdf). The molecular formula is C38H52N6O7 H2SO4; the molecular weight of the sulfuric acid salt is 802.9; the molecular weight of the free base is 704.9. The structure is shown in Figure 246.1. Atazanavir sulfate is a white-yellow crystalline powder and slightly soluble in water; the pH of a saturated solution in water is 1.9 (at 24 ± 3°C). Atazanavir belongs to the protease inhibitor class of antiretroviral agents. Structure of atazanavir sulfate. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig246_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
