ABSTRACT
Cefotaxime is a third-generation or extended-spectrum cephalosporin which was developed in the 1970s and approved by the US Food and Drug Administration (FDA) in 1981. Cefotaxime is (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; its formula is C16H17N5O7S2, and its molecular weight is 455.46548 g/mol. The chemical structure of cefotaxime is shown in Figure 26.1.
