ABSTRACT
Extended-spectrum, or third-generation cephalosporins, were developed after the first-and second-generation drugs. Due to their prominence, ceftriaxone (see Chapter 27, Ceftriaxone), cefotaxime (see Chapter 26, Cefotaxime), and ceftazidime (see Chapter 30, Ceftazidime and ceftazidime–avibactam) are discussed in detail in their own chapters. However, other third-generation cephalosporins, such as ceftizoxime, cefdinir, cefditoren, cefpodoxime, ceftibuten, cefsulodin, and cefpiramide, are available in only certain countries or are seldom if ever used in contemporary practice. Description of these antibiotics is therefore limited, with the exception of ceftizoxime (as a representative of a parenterally administered third-generation cephalosporin) and cefpodoxime (as a representative of an orally administered third-generation cephalosporin).
