ABSTRACT

Cefepime is an oxymino beta-lactam with an amino thiazoline side chain classified as the representative drug for the fourth-generation cephalosporins. It has a wider spectrum and greater potency than the third-generation cephalosporins. Cefepime shows high stability against some beta-lactamases, most notably the AmpC chromosomal and plasmid-mediated enzymes produced by Gram-negative pathogens (Endimiani et al., 2008). The molecular weight of cefepime is 480.56, and its chemical formula is C19H25N6O5S2. Its structure is illustrated in Figure 31.1.