ABSTRACT
Ceftaroline, also referred to as PPI-0903M or T-91825, is a fifth-generation parental oxyimino cephalosporin with bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA). Ceftaroline is the bioactive metabolite of ceftaroline fosamil, formerly PPI-0903 or TAK-599, an N-phosphono-amino water-soluble cephalosporin prodrug (Iizawa et al., 2004). Similar to ceftobiprole, it shows potent activity against MRSA, while maintaining the broad Gram-negative activity and favorable safety profile of cephalosporins. The structures of ceftaroline and ceftaroline fosamil are illustrated in Figure 32.1 (Iizawa et al., 2004). The structure of (a) ceftaroline and (b) ceftaroline fosamil. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig32_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
