ABSTRACT
Ceftolozane (also known as CXA101 and FR264205) is an oxyimino-aminothiazolyl cephalosporin with structural similarity to ceftazidime (Toda et al., 2008). The addition of a 3-amino-2-methylpyrazole in the 4-position improved the minimum inhibitory concentrations against class C beta-lactamase-producing organisms (Toda et al., 2008). The spectrum of activity includes Gram-negative bacilli, such as Pseudomonas aeruginosa and many Enterobacteriaceae as well as those expressing some beta-lactamases (e.g. OXA-1, SHV-1, TEM-1 and -2) (Takeda et al., 2007).
