ABSTRACT
Doripenem (formerly S-4661), (4R,5S,6S)-3-{[(3S,5S)-5-(sulfamoyla-minomethyl)-pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo (3.2.0) hept-2-ene-2-carboxylic acid (molecular formula, C15H24N4O6S2; molecular weight, 420.50426) is a synthetic 1-beta-methylcarbapenem developed by Shionogi & Co. Ltd. (Osaka, Japan) (Iso et al., 1996). The chemical structure of doripenem is similar to that of meropenem (Anderson, 2006) (see Figure 39.1). In doripenem, the dimethylcarbamoyl side chain of meropenem is replaced by a sulfamoylaminomethyl group (Jones et al., 2004b; Anderson, 2006).
