Biapenem, Ritipenem, Panipenem, and Sulopenem

Biapenem is a parenteral carbapenem antibiotic that possesses antibacterial activities against a wide range of Gram-positive and negative bacteria (Ubukata et al., 1990; Perry and Ibbotson, 2002). The introduction of the methyl radical at the 1-beta position of the carbapenem skeleton gives biapenem stability against hydrolysis by renal dehydropeptidase-1 (DHP-1). Therefore biapenem does not require concomitant administration of an inhibitor of this enzyme (Ubukata et al., 1990; Petersen et al., 1991; Hikida et al., 1992a). The molecular formula for biapenem is C₁₅H₁₈N₄O₄S, and its molecular weight is 350.39; the chemical structure is shown in Figure 42.1. Figure 42.1 Chemical structure of biapenem. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig42_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>