ABSTRACT
Telavancin (Vibativ, TD-6424; Theravance Inc., San Francisco, CA) is a semisynthetic derivate of vancomycin featuring a lipophilic side chain (decyl-aminoethyl) and a hydrophilic moiety (phosphonomethyl aminomethyl) on the 4′-position of amino acid 7, which is attached to a vancosamine sugar (Leadbetter et al., 2004; Pace and Judice, 2005). The addition of the lipophilic side chain classifies this agent as a lipoglycopeptide similar to oritavancin (see Chapter 46, Oritavancin) and dalbavancin (see Chapter 47, Dalbavancin). The molecular formula is C80H106Cl2N11O27P, and its molecular weight 1755.6; the chemical structure is shown in Figure 48.1. Molecular structure of telavancin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig48_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
