ABSTRACT
Tobramycin is an aminoglycoside aminocyclitol antibiotic, which is one of several compounds in an antibiotic complex (nebramycin) produced by Streptomyces tenebrarius. The molecular formula for tobramycin is C18H37N5O9; the corresponding molecular weight is 467.5, and the molecular structure is shown in Figure 53.1. Tobramycin is used clinically both as a sulfate salt and in a nebulizer solution in sodium chloride and without preservatives for inhalation. It is a drug similar to gentamicin (see Chapter 52, Gentamicin), but its advantages include greater intrinsic activity against Pseudomonas aeruginosa, activity against some gentamicin-resistant P. aeruginosa and Acinetobacter baumannii strains, and lesser nephrotoxicity. Molecular structure of tobramycin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig53_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
