Amikacin

Amikacin is a semisynthetic aminoglycoside antibiotic. It was derived by the addition of the (S)-4-amino-2-hydroxybutyryl (AHB) side chain into the 1-amino position of the deoxystreptamine moiety of kanamycin A (Kawaguchi, 1976; Pien and Ho, 1981). The empirical formula of amikacin is C₂₂H₄₃N₅O₁₃, and the molecular weight is 585.6; the molecular structure of amikacin is shown in Figure 54.1. Figure 54.1 Molecular structure of amikacin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig54_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>