ABSTRACT
Plazomicin, a semisynthetic aminoglycoside based on sisomicin, was designed by scientists at Achaogen to avoid enzymatic inactivation by common aminoglycoside-modifying enzymes (AMEs) (Aggen et al., 2010). The molecular formula for plazomicin is C25H48N6O10 with a corresponding molecular weight of 592.68 (SciFinder, CAS Registry Number 1154757-24-0). The molecular structure of plazomicin, a sisomicin derivative with 1-hydroxyaminobutyric acid and 6-hydroxyethyl substituents, is shown in Figure 58.1. Its mechanism of action is similar to that of the other aminoglycosides, that is, binding to the bacterial ribosome, resulting in the cessation of protein synthesis (Aggen et al., 2010). It is currently under development for the treatment of serious antibiotic-resistant infections caused by enteric bacteria (Bassetti and Righi, 2015). Molecular structure of plazomicin. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig58_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
