ABSTRACT
Cadazolid (formerly ACT-179811) is a nonabsorbable, fluoroquinolone-oxazolidinone class antibiotic that inhibits bacterial protein synthesis. The substance is moderately lipophilic (log D = 1.2), acidic (pKa = 6.0), and poorly soluble in aqueous solution (150 ng/ml). Its chemical structure is formally [(R)-1-cyclopropyl-6-fluoro-7-{4-[2-fluoro-4-(5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid], and the molecular formula is C29H29N3O8F2 (Baldoni et al, 2014) (Figure 74.1). Chemical structure of cadazolid. [(R)-1-cyclopropyl-6-fluoro-7-{4-[2-fluoro-4-(5-hydroxymethyl-2-oxo-oxazolidin-3-yl) phenoxymethyl]-4-hydroxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid] (<xref ref-type="bibr" rid="ref74_9">Locher <italic>et al</italic>., 2014b</xref>). https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig74_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>
