ABSTRACT
Nafcillin, 6-(2-ethoxy-1-naphthamido) penicillanic acid, is a semisynthetic penicillin derived from the penicillin nucleus, 6-aminopeni-cillanic acid. Similar to methicillin and the isoxazolyl penicillins, it is resistant to staphylococcal penicillinase and has a predominately Gram-positive spectrum. Developed in 1961, it has since been widely used in the USA and a small number of other countries for the parenteral treatment of serious beta-lactamase-producing staphylococcal infections.
