Trimetrexate

Trimetrexate (as trimetrexate glucuronate) was marketed under the brand name Neutrexin. Its molecular weight is 369.4 (trimetrexate) and 563.6 for trimetrexate glucuronate. Its chemical formula is 2,4-diamino-5-methyl-6-([3,4,5-trimethoxy-phenyl] aminomethyl) quinazoline, with an empiric formula of C₁₉H₂₃N₅O₃ (trimetrexate glucuronate: C₁₉H₂₃N₅O_3,C₆H₁₀O₇; see Figure 95.1). Figure 95.1 Structure of trimetrexate. https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315152110/08d8042d-9481-4a8d-8c27-9bd589f6de6b/content/fig95_1.tif" xmlns:xlink="https://www.w3.org/1999/xlink"/>