ABSTRACT
Iclaprim (previously known as AR-100 and Ro 48-2622) is a new member of the diaminopyrimidine class of antimicrobials, to which trimethoprim also belongs. As with trimethoprim, iclaprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), an enzyme in the folate synthesis pathway. The two potential advantages of iclaprim compared with trimethoprim are an increased affinity for bacterial DHFR, particularly in Gram-positive bacteria, and activity against trimethoprim-resistant organisms. Iclaprim is therefore a potentially interesting new agent for the treatment of multiresistant Gram-positive infections.
