ABSTRACT
Following the success of genome sequencing, DNA microarray technology has emerged as a valuable tool in the exploration of genome functionality. cDNA microarrays (Schena et al., 1995; Lockhart et al., 1996) consist of thousands of individual DNA sequences printed on a high density array using a robotic arrayer. A microarray works by exploiting the ability of a given labeled cDNA molecule to bind specifically to, or hybridize to, a complementary sequence on the array. By using an array containing many DNA samples, scientists can measure-in a single experiment-the expression levels of thousands of genes within a cell by measuring the amount of labeled cDNA bound to each site on the array. A common task with microarrays is to determine which genes are differentially expressed under two or more experimental conditions.
