Bayes and Empirical Bayes Methods for Spotted Microarray Data Analysis

With a two-color competitive hybridization process, spotted microarrays provide a genome-wide measure of differential gene expression levels in two or more samples as well as controlling for undesirable effects (Schena et al.;24

Brown and Botstein3). While the microarray experiment is powerful in profiling thousands or even millions of genes simultaneously, it holds challenges in technology as presenting reliable reading for each gene, and in statistics as extracting useful information and essentially making sensible conclusions from the enormous amount of data.