ABSTRACT

External electric eld, which is applied to cells, can, under suitable eld parameters, induce local distortions and structural rearrangements of lipid molecules in the cell membrane. Depending on the eld parameters, the membrane hence becomes either transiently or permanently permeable even a´er the eld has ceased, allowing molecules that are otherwise deprived of transport mechanisms to cross the membrane and reach the cytosol. is phenomenon is o´en referred to as electroporation or electropermeabilization.