While any one particular strain of mice may not fully capture the immunopathology of the entire spectrum of human tuberculosis, the combined information from various genetic backgrounds would capture the spectrum adequately. Apt and Kramnik (Apt and Kramnik, 2009) in their recent commentary have pointed out that the spectrum of human tuberculosis in terms of pathophysiology can be explained due to the large degree of heterogeneity in the human population, and that the lack of a spectrum of pathophysiological phenotypes in mice is simply due to the fact that one is focused to one inbred strain or the other. Against this background, it is important to note that the present set of histopathological observations is from only one strain of mice, namely BALB/c, and from a single set of infection conditions. erefore, it is not unexpected that the full gamut of histopathological ndings associated with human tuberculosis will not be seen in this section (Figure 10.1 and Figure 10.2).