INTRODUCTION Cell migration is fundamental to a number of physiological processes such as embryogenesis, organ growth, inammation, wound healing, and tumor-induced angiogenesis. In embryonic development, the blastocyst cells migrate to form layers (gastrulation) and later migrate to target destinations in the developing embryo to specialize and become components of organs. is process of developmental migration continues in the adult, as some cells in our bodies are born, migrate, and die on a daily basis. Wound healing is another example of collective cell migration, involving the proliferation of existing cells and the migration of cells close to the wound towards each other to close the cle. In the pathological context, enhanced cell migration is key to invasive growth of tumor cells, which is the basis of metastasis. is invasion involves the detachment of individual cells from their originating tissue and is followed by their propulsion through existing tissue.