ABSTRACT

Looking broadly, Raman scattering and MIR absorption are key technologies in several biomedical research areas. ™ey are excellent at detecting slight dižerences between types of cells or tissues. ™is makes them good for subtle classi›cation tasks, either in point sampling (e.g., bacterial identi›cation) or in image analysis (e.g., tissue histology). O²en, vibrational spectroscopy can detect dižerences between specimens when other, more widespread optical methods cannot. Vibrational spectroscopy is also well-suited for measuring biochemical concentrations, particularly in situations where the target chemical exists

in the presence of other, higher-concentration interferents. In both cases (classi›cation and quanti›cation), vibrational spectroscopy accomplishes this on the strength of the unusually rich spectrum of information it provides.