ABSTRACT
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The tissues of the human body contain signi‰cant extracellular space, into which extracellular matrix (ECM) molecules are secreted by the cells to form a complex hydrogel network. The ECM provides mechanical support for tissues, organizes cells into speci‰c tissues, and controls cell behavior. In other words, ECM is a dynamic structure that provides structural and anchoring support to the cells to improve tissue architecture. It also contributes to signaling, directing cell fate and function through cell-matrix interactions. In addition, the ECM is constantly remodeled by cells during development, homeostasis, and wound healing by balancing its synthesis and degradation by a variety of enzymes.
