ABSTRACT
Poor water solubility of new chemical entities has reached a high level of importance in the pharmaceutical world. The formulation of these challenging drug candidates required the implementation of novel drug delivery technologies over the last 30 years. The need for new technological approaches has arisen from the applications of novel drug discovery methods, such as high throughput screening and computer-aided drug design. However, the large number of poorly soluble compounds is also a result of novel diseases with novel molecular targets, which require often more lipophilic structures for a better receptor fi tting and membrane permeability (Rabinow 2004).
