ABSTRACT

Cellular therapeutics has recently emerged as a new way to treat or possibly cure myriad diseases. This includes the use of immune cells, including dendritic cell cancer vaccine for immunotherapy of cancer (Figdor et al. 2004), and progenitor and stem cells for repair of degenerative diseases (Fink 2009). To further guide these therapies into the clinic, the use of noninvasive imaging techniques is mandatory. These need to be applied not only to guide the cell injection itself but also to report on subsequent cell fate, including cell survival, cell movements, and cell differentiation (in the case of stem cells).