Systems engineering has evolved into a formal discipline with the flexibility to adapt to various modes of system development. But some specific core functions are always present: define, control, validate, and verify requirements; determine system architecture; define and control interfaces; and so forth. When introducing something truly new into a development effort, such as micro-or nanoscale technologies (MNT), the natural tendency is to manage the technology and the overall system developments in the usual, established way. This may result in a “forced fit” at first. As experience accrues, it may become evident that a different approach is needed. This chapter will look at the potential impacts of using early-generation MNT in a system and the application of traditional technology development strategies.