ABSTRACT
Each model type generates dierent kinds of information about cancer; each type contributes to the translational toolbox, and has strengths and limitations. erefore, it is important to employ the appropriate type for specic research questions. For example, spontaneous tumor models are useful to expose the natural variation and interactions among background genetic elements that promote tumor development. ey support experiments to examine the stochastic processes that contribute to each stage of progression. However, many spontaneous models develop tumors at a number of sites, unlike the majority of cancer
patients. In addition, there is oen inconsistency in the numbers and timing of tumors among littermates. Researchers do use various breeding schemes to reduce variability, although this can be costly and doing so may select against informative subtle background genetic contributions.
