ABSTRACT
Nanoscience denotes an interdisciplinary fi eld, dealing with phenomena, or creation of devices in a range smaller than 1 µm (typically 1 to 100 nm). Two main approaches were made to produce nano-particles and devices: the bottom-up, and the top-down approach. The bottom-up approach works at molecular level by chemical composition. The top-down approach
reaches its aims by bringing larger entities to nanolevel without affecting the molecular level (Merkoci 2009). Nanomaterials were implemented in bioanalytical applications to achieve highly sensitive and robust methods. By decreasing particle size to nanolevel, a change of the physicochemical properties take place. The increased surface-to-volume ratio and the unusual binding affi nities depending on size, shape and molecular structure are interesting aspects for analytical applications (Merkoci 2009).
