Porous media are encountered in many man-made systems and in industrial processes such as in fuel cells, paper pulp drying, food production, diverse filtration methods, concrete, ceramics, moisture absorbents, textiles, paint drying, polymer composites, various wood applications, etc. There is also a growing interest in biological tissues, biomechanics of organic porous tissues and in engineering tissues. Porous media are obviously encountered in many natural systems involving multiphase flow, energy and solute transport in soils, aquifers, geothermal, oil and gas reservoirs. In this chapter attention is focused on the modeling of the thermo-poroelastic behavior of porous rocks.