ABSTRACT
Mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs) have a great demand in tissue engineering and regenerative medicine because of their high in vitro expansion potential, self-renewal capacity, multipotentiality, and immunomodulatory properties (Deans and Moseley 2000). However, considering the limited availability, invasive collection procedure and donor age-related differences that inuence both proliferative and differentiation capacity of autologous adult stem cells particularly bone marrow stromal cells which is “the gold standard,” there is an increasing interest in the investigation of using fetal-derived MSCs as an allogenic stem cell source for the previously said applications (Romanov et al. 2003).
