ABSTRACT

The kinetic binding and release rates of FA proteins were determined with Fluorescence Recovery After Photobleaching (FRAP) studies [27-35]. In these studies,

the transmembrane protein integrin showed a delayed recovery. It was suggested that the diffusion of integrin into an FA may be severely hindered by the dense structure of the FA. Since integrin forms the base of an FA, such a diffusional hindrance could be the basis of an edge-on growth mechanism.