ABSTRACT
Saenko A.S. 1, Zamulaeva I.A., Orlova N.V., Smirnova S.G., Selivanova E.l., Matveeva N.P., and Kaplan M.A.
Medical Radiological Scientific Center, Russian Academy of Medical Sciences, Obninsk, the Russian Federation
Frequency analysis of somatic cell with gene mutations by glycophorin A (GPA) and T-cell receptor (TCR) loci was performed on liquidators of the Chernobyl Accident irradiated in doses up to 0.25 Gy and control persons. The effectiveness of damaged cell apoptotic elimination in these persons was studies and then this index was compared with mutant cell frequency in TCR-locus. The following regularities of long date somatic mutagenesis after low dose irradiation were determined:
the average frequency if PCR-mutant lymphocytes increases and the quantity of mutant hemopoietic stem cells is preserved at the control level. It was judged about by the quantity of GPA (NO)-variant erythrocytes; the absence of monotonic dependence between TCR-mutant cell frequency and the irradiation dose; preservation of stable effect (increased frequency of TCR-mutant lymphocytes) during 9-17 years after irradiation impact; the effect manifestation in part of irradiated persons.
