ABSTRACT
Selenium (Se) is an essential trace element and absorbed selenium in the body is incorporated in selenocystine which is needed for synthesis of a number of important selenoproteins (Thomson 2004; Lobanov 2009). The arsenic-selenium antagonism has been demonstrated in various animal models and reported in literature (Gailer 2009; Gailer et al. 2000). Selenium is a potential chemopreventive agent for Arsenic (As) cancer. Selenium has been reported to form a complex selenobis(S-glutathionyl)arsinium ion in equimolar ratio with arsenic as a major metabolite in the liver and biliary tree and excreted (Gailer et al. 2000). Formation of this complex ion and hepatobiliary excretion is one of the basis of selenium countering arsenic toxicity.
