Arsenic trioxide enhances radiation sensitivity of androgen-dependent and -independent human prostate cancer cells

In the present study, LNCaP (androgen-sensitive human prostate cancer cells) and PC-3 cells (androgen-independent human prostate cancer cells) were used to investigate the anti-cancer effects of IR combined with ATO. The types of cell death induced by IR combined with ATO were examined. We also investigated the possible mechanisms underlying apoptosis or autophagy in LNCaP and PC-3 cells induced by IR and/or ATO.