The Amyloid Precursor Protein is a highly studied protein due to its assumed central role in the pathogenic pathway that leads to Alzheimer’s disease. It is expressed into a number of isoforms and undergoes complex proteolytic processing. Structural, biochemical and cellular data identify the Amyloid Precursor Protein as copper binding protein. This interaction modulates Amyloid Precursor Protein metabolism as well as copper homeostasis. This interaction could also have a direct impact upon the pathogenic pathway that causes Alzheimer’s diseases.