ABSTRACT

Background Bone marrow-derived stromal cells (BMSCs), also known as mesenchymal stem cells or nonhematopoietic progenitor cells, are precursors that can be dierentiated into chondrocytes, osteoblasts, adipocytes, neurons and other cell types [1]. ey are important for development and cell replenishment of active proliferating tissues in physiological conditions, such as blood, skin and gut. In pathological conditions, they are involved in the process of wound healing and tissue regeneration. In animal and clinical experiments, BMSCs have been used for tissue damage repair and functional reconstruction of organs, such as myocardial infarction, osteogenesis imperfecta, syndrome of multiple organ failure and rebuilding of hematopoietic system after chemotherapy of breast cancer [2-5].