ABSTRACT
Miniaturization (and its applications to make human life more comfortable) has been one of the key features of the technological progress of the past few decades. Micro total analysis systems (μ-TAS), where it is possible to organize and combine the processes of sample handling, analysis, and detection in stand-alone integrated microfluidic platforms, is a glowing representation of the success of such miniaturization (Auroux et al., 2002; Reyes et al., 2002; Lee and Lee, 2004; Vilkner et al., 2004). And, μ-TAS is one of the several bio-microfluidic-based devices that have achieved immense popularity in detecting pathological abnormalities and illness in patients. The key to such detection is to have observable signals that are signatures of well-established chemical reactions/processes. For example, for viral infections or blood-related pathologies, one can perform immunoassays to determine the nature of miscreant organisms (Lequin, 2005; Yolken et al., 2006). One can either employ a homogeneous system where the sample and the detection molecules are both in a liquid system (Truchaud et al., 1991), or a
CONTENTS
7.1 Introduction ................................................................................................ 215 7.2 Mathematical Modeling of Microflow-Driven DNA Hybridization .. 218
7.2.1 Governing Equations .................................................................... 218 7.2.2 Simplified Analytical Considerations ......................................... 224 7.2.3 Numerical Simulation Predictions ..............................................229
