ABSTRACT
This chapter focuses on the hybridization reaction and on its modeling and simulation in microsystems. In microsystems, hybridization reactions are performed at the walls, on an active surface. In a cylindrical tube, a laminar flow field of a Newtonian fluid is determined by the Poiseuille–Hagen relation, and the velocity profile is quadratic. In microsystems for biotechnology, due to flow laminarity, the velocity field can be extremely well calculated. The development of biotechnology, and micro and nano-technologies in general, is sufficiently mature for numerical modeling and simulation to develop quickly. The first microfluidic systems for biotechnology used conventional liquids, like water, or aqueous solutions and organic liquids, like mineral oil. Mixing is difficult in microsystems because of the high laminarity of the flows. If only passive methods are usedin order to keep the system simpleonly difusion contributes to mixing.
