ABSTRACT
INTRODUCTION The ocular surface is rich in complexity and functionality; consisting of the eyelids, tear fi lm, conjunctiva, and cornea. Severe ocular surface disease
1Hospital Clínico Universitario Valladolid-University of Valladolid, Paseo Ramón y Cajal 3, 47011 Valladolid, Spain. aE-mail: davidgalarreta@hotmail.com 2Instituto Universitario de Oftalmobiología Aplicada (IOBA-Eye Institute)—University of Valladolid, Paseo de Belén, 17-Campus Miguel Delibes, 47011 Valladolid, Spain. *Corresponding author
(OSD) may affect every single component of the functional unit. The wider the affected area, the more diffi cult is the treatment and the reconstruction procedures. The steps in the treatment must be orientated to provide better conditions to the cornea. To achieve this homeostasis is vital for the maintenance of good corneal epithelium, which is needed to keep corneal clarity and the optical function.
