ABSTRACT

Growth impairment is frequently seen following successful cancer treatment in children. In many patients, this results in reduced statural growth and final height. Although radiation-induced GH deficiency is a common cause of growth impairment in cancer survivors, a variety of other factors could also contribute, including the disease process itself, decreased nutritional intake, psychosocial dysfunction, chemotherapy, steroid therapy, spinal irradiation, hypothyroidism, hypogonadism, precocious puberty and the non-endocrine complications of various treatment modalities.