ABSTRACT
Introduction 499 Cell morphology 499 Plasma cell differentiation 499 Follicular colonization 499 Tumor progression 500 Extranodal marginal zone B cell lymphoma 500 History and definition 500 Morphology 500 Epidemiology 501 Etiologic factors 501 Immunophenotype 502 Genetics 502 Prognosis and predictive factors 504 Are diffuse large B cell lymphomas at extranodal sites 504
high-grade marginal zone lymphomas? Nodal marginal zone B cell lymphoma 505 Definition 505 Sites of involvement 505
Clinical features 505 Pediatric nodal marginal zone lymphoma 505 Morphology 505 Immunohistochemistry 506 Differential diagnosis 506 Genetics 506 Prognosis and predictive factors 506 Splenic marginal zone lymphoma 506 Sites of involvement 506 Clinical features 507 Morphology 507 Immunophenotype 507 Genetics 507 Prognosis and predictive factors 508 Splenic marginal zone lymphoma and hepatitis C 508
virus infection Key points 508 References 508
This chapter discusses three different categories of lymphoma:
● extranodal marginal zone lymphoma (EMZL); ● nodal marginal zone lymphoma (NMZL); ● splenic marginal zone lymphoma (SMZL).
